The evolution of clinical decision support systems (CDSS) has reached a critical inflection point where traditional reference models are being supplanted by agentic, multi-model architectures. At the center of this transition is OpenEvidence, a platform that has ascended to a $12 Billion valuation in less than a year of public operations. This rapid scaling is fundamentally a response to the "human problem" identified by the platform’s founder, Daniel Nadler: the exponential