HealthTech M&A Multiples June 2025: Current Trends and Variables driving valuations
- Lloyd Price
- 11 hours ago
- 10 min read
Current Trends in HealthTech M&A Multiples
As of June 2025, the HealthTech M&A landscape continues to be shaped by a blend of opportunity, innovation, and caution, with valuation multiples reflecting both market dynamics and specific company attributes.
Revenue Multiples: The average revenue multiple for HealthTech companies in 2025 is between 4-6x for most companies, however specific sub-sectors and company profiles influence this range:
AI, Telehealth, and Analytics: Companies with proprietary AI algorithms, scalable telehealth platforms, or advanced analytics are commanding higher multiples, potentially 6-8x revenue, due to strong buyer interest from pharmaceuticals, hospitals, and private equity (PE) firms. This is driven by the transformative potential of these technologies in diagnostics, drug discovery, and patient care.
Smaller or Unprofitable Startups: Early-stage or unprofitable HealthTech startups may face downward pressure, with multiples compressing to 3-4x revenue unless they demonstrate clear profitability paths or attract strategic buyers.
Biotech-Adjacent HealthTech: Late-stage innovators, particularly those addressing Big Pharma’s patent cliffs, could see outlier multiples of 7-8x or higher, especially in areas like novel therapeutics or digital health solutions integrated with biotech.
Wellness Companies: These typically see lower multiples compared to other sub-sectors due to lower profit margins and consumer-focused models, often closer to 3-5x revenue.
EBITDA Multiples: For HealthTech companies with positive earnings, enterprise value (EV) to EBITDA multiples range from 10-14x, slightly up from 2024’s 10-12.5x, reflecting cautious optimism in the market. Public company EBITDA multiples in health services have risen marginally from 13.5x (end of 2023) to 14.0x (November 2024), indicating stability.
Deal Volume and Market Sentiment: HealthTech M&A deal volumes remain robust, supported by significant available capital from corporate and PE buyers, despite a 9% decline in health services deal volume through November 2024 compared to 2023. The sector’s resilience is evident, with deal activity nearly 70% above pre-COVID levels, driven by expectations of interest rate cuts and a pro-business regulatory stance in 2025.
Key Variables Driving Valuations
The following factors significantly influence HealthTech M&A valuation multiples in 2025:
Stage of Company Development: Early-stage companies typically command lower multiples due to higher risk, while mature companies with established revenue streams and profitability see higher valuations. Early-stage firms are valued based on growth potential, while mature firms are tied to revenue and profitability metrics.
Company Size: Larger companies generally attract higher multiples due to their scale, market presence, and lower perceived risk. Smaller companies may command higher multiples if they offer strategic value, such as innovative technologies or access to new markets.
Intellectual Property (IP) Portfolio: Companies with strong, defensible IP, particularly in AI, digital therapeutics, or novel medical devices, are valued at a premium due to their competitive advantage and barriers to entry.
Revenue Growth: Strong revenue growth remains a critical driver, with companies demonstrating consistent growth commanding premium valuations. For example, telehealth companies with rapid growth often see higher multiples due to their disruptive potential.
Gross Margin: Higher gross margins signal profitability potential, leading to higher multiples. Companies with efficient operations and high margins are more attractive to buyers.
Customer Acquisition Costs (CAC): Lower CACs enhance valuations, as they indicate efficient scaling and market acceptance. B2B-focused HealthTech firms, such as those offering revenue cycle management (RCM) solutions, often have lower CACs compared to direct-to-consumer (DTC) models, driving higher valuations.
Market Share: Companies with significant market share in their niche, such as telehealth or health analytics, are valued at a premium due to their dominance and ability to influence industry trends.
Regulatory Landscape: A favorable regulatory environment boosts valuations, while uncertainty or stringent regulations (e.g., antitrust scrutiny) can suppress multiples. The 2025 market anticipates lighter U.S. regulations, potentially increasing deal activity.
Technology Moat: A strong technology moat—such as proprietary AI, unique algorithms, or scalable platforms—creates a competitive edge, leading to higher valuations. This is particularly relevant for AI-driven HealthTech firms.
Strategic Fit and Market Dynamics: Buyers, including large pharma and PE firms, are prioritizing acquisitions that fill portfolio gaps or enhance capabilities in high-growth areas like AI, telehealth, and health analytics. The looming patent cliffs for Big Pharma are driving acquisitions of innovative HealthTech firms to bolster pipelines.
Market Trends in June 2025
Distressed M&A Activity: An increase in distressed company M&As in 2025 is influencing valuations, particularly for smaller, unprofitable startups facing funding challenges. These firms may see compressed multiples unless acquired by strategic buyers seeking innovation at a discount.
AI and Tech-Enabled Solutions: AI-driven HealthTech, particularly in diagnostics, drug discovery, and administrative functions (e.g., RCM, care coordination), is a hotspot for M&A activity. Investors are prioritising B2B solutions over DTC due to lower CACs and stronger profitability prospects.
Regulatory and Antitrust Scrutiny: Heightened regulatory oversight, such as the FTC’s focus on antitrust (e.g., blocking UnitedHealth’s $3.3B acquisition of Amedisys), is creating valuation gaps and hesitation in some deals. However, optimism around a pro-business U.S. administration in 2025 is expected to ease these concerns.
Private Equity and Capital Deployment: PE firms are sitting on significant capital and are targeting HealthTech, particularly in medtech, digital health, and B2B solutions like RCM software. This is driving competition and sustaining higher multiples for quality assets.
Portfolio Optimisation: Large pharma and health systems are divesting non-core assets to fund acquisitions in high-growth HealthTech areas, further fuelling deal activity.
The HealthTech M&A market in June 2025 is expected to remain active, with multiples holding steady at 4-6x revenue for most firms but trending higher (6-8x or more) for AI-driven, telehealth, or biotech-adjacent companies with strong IP or growth profiles. Economic factors, such as potential interest rate cuts and easing regulatory pressures, are likely to bolster deal volumes. However, valuation misalignment and regulatory scrutiny may continue to challenge some transactions, particularly in highly competitive sub-sectors. Companies with strong technology moats, high revenue growth, and low CACs will likely command the highest premiums, while distressed or unprofitable firms face valuation compression unless strategically acquired.
Nelson Advisors > Healthcare Technology M&A
.
Nelson Advisors specialise in mergers, acquisitions & partnerships for Digital Health, HealthTech, Health IT, Consumer HealthTech, Healthcare Cybersecurity, Healthcare AI companies based in the UK, Europe and North America. www.nelsonadvisors.co.uk
Nelson Advisors regularly publish Healthcare Technology thought leadership articles covering market insights, trends, analysis & predictions @ https://www.healthcare.digital
We share our views on the latest Healthcare Technology mergers, acquisitions & partnerships with insights, analysis and predictions in our LinkedIn Newsletter every week, subscribe today! https://lnkd.in/e5hTp_xb
Founders for Founders > We pride ourselves on our DNA as ‘HealthTech entrepreneurs advising HealthTech entrepreneurs.’ Nelson Advisors partner with entrepreneurs, boards and investors to maximise shareholder value and investment returns. www.nelsonadvisors.co.uk
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HealthTech M&A valuation multiples
HealthTech M&A valuation multiples are a set of metrics used to determine the value of a HealthTech company in an acquisition or merger.
These multiples are typically based on financial metrics such as revenue, earnings, or users/subscribers, and can differ based on the company's stage of development, growth prospects, market position, and other relevant factors.
Some of the most commonly used HealthTech M&A valuation multiples include:
Enterprise value (EV) to sales: This multiple is the most common way to value healthtech companies. It is calculated by dividing the company's enterprise value (EV) by its trailing 12-month revenue.
EV to EBITDA: This multiple is used to measure a company's profitability. It is calculated by dividing the company's EV by its earnings before interest, taxes, depreciation, and amortization (EBITDA).
Price to earnings (P/E) ratio: This multiple is used to measure a company's valuation relative to its earnings. It is calculated by dividing the company's stock price by its earnings per share (EPS).
Price to sales (P/S) ratio: This multiple is used to measure a company's valuation relative to its sales. It is calculated by dividing the company's stock price by its trailing 12-month revenue.
The specific multiple that is used to value a HealthTech company will depend on a number of factors, including the company's stage of development, growth prospects, market position, and other relevant factors. However, the multiples listed above are a good starting point for understanding how HealthTech companies are valued in M&A transactions.
It is important to note that valuation multiples are just one factor that is considered when valuing a healthtech company. Other factors, such as the company's management team, its intellectual property, and its strategic positioning, can also play a role in determining the company's valuation.
Here are some of the recent trends in HealthTech M&A valuation multiples:
Valuation multiples vary depending on the sub-sector of healthtech. For example, companies in the telehealth sector typically command higher valuation multiples than companies in the medical device sector.
Valuation multiples are also affected by the stage of development of the company. Companies that are still in the early stages of development typically command lower valuation multiples than companies that are more mature.
Valuation multiples have been increasing in recent years. This is due to a number of factors, including the growing demand for digital health solutions, the increasing investment in healthtech by venture capitalists, and the favourable regulatory environment for healthtech companies.
What are the biggest trends likely to affect healthcare technology multiples in 2025?
1. AI Integration and Innovation
What’s Happening: Artificial intelligence is transforming diagnostics, drug discovery, and patient care (e.g., predictive analytics, imaging AI). HealthTech firms with proprietary AI algorithms or scalable platforms are seeing heightened interest from buyers like pharma and hospitals.
Impact on Multiples: Companies with proven AI solutions could see multiples rise to 6-8x revenue, above the sector average of 4.5-5x, as buyers pay premiums for innovation and future revenue potential. Firms lagging in AI adoption may face compression toward 3-4x.
Why It Matters: AI’s ability to cut costs and improve outcomes aligns with healthcare’s biggest challenges, amplifying valuations for leaders.
2. Regulatory Evolution and Clarity
What’s Happening: Regulatory bodies like the FDA are refining frameworks for digital health tools (e.g., Software as a Medical Device) and AI approvals. Post-2024 U.S. election, a pro-business administration might ease compliance burdens further.
Impact on Multiples: Clear regulatory pathways boost confidence, lifting multiples by 0.5-1x for compliant firms (e.g., 5-6x vs. 4-5x). Uncertainty or delays, however, could cap multiples or deter deals, especially for early-stage companies.
Why It Matters: Regulatory approval signals scalability and reduces risk, key drivers of M&A premiums.
3. Shift to Value-Based Care
What’s Happening: Healthcare is moving from fee-for-service to value-based models, prioritizing outcomes over volume. HealthTech enabling this shift—think remote monitoring, population health analytics—gains traction with payers and providers.
Impact on Multiples: Companies aligned with value-based care (e.g., chronic disease platforms) could see multiples climb to 5.5-7x, reflecting strategic fit. Non-aligned firms might stagnate at 3-4x.
Why It Matters: Buyers like insurers and health systems pay more for tech that delivers measurable cost savings and patient outcomes, a growing priority in 2025.
4. Telehealth Maturation and Hybrid Models
What’s Happening: Telehealth is evolving beyond standalone platforms into hybrid care models, integrating with in-person services (e.g., CVS Health’s primary care push). Growth has slowed from pandemic peaks, but adoption remains strong.
Impact on Multiples: Mature telehealth firms with profitability or hybrid offerings sustain 5-7x multiples, while unprofitable pure-plays may drop to 4-5x. Strategic synergies with buyers could push outliers higher.
Why It Matters: Telehealth’s stickiness and cost-efficiency keep it a premium subsector, though differentiation is now key.
5. Economic Recovery and Capital Availability
What’s Happening: Falling interest rates in 2025 and $171 billion in pharma cash reserves (per late 2024 estimates) are thawing M&A markets. Private equity and strategic buyers are re-entering HealthTech with renewed vigour.
Impact on Multiples: Increased deal competition could lift averages by 0.5x (e.g., 4.9x to 5.4x), especially for high-growth firms. Smaller or riskier targets might still see discounts if capital prioritizes proven winners.
Why It Matters: Cheaper financing and cash-rich buyers fuel bidding wars, inflating valuations for desirable assets.
6. Data Monetisation and Interoperability
What’s Happening: HealthTech firms that leverage patient data ethically (e.g., via analytics or interoperability with EHRs) are unlocking new revenue streams. Regulatory pressure for data sharing (e.g., 21st Century Cures Act) accelerates this trend.
Impact on Multiples: Data-driven companies could command 5.5-7x multiples, as buyers value clean, actionable data. Firms with siloed or insecure data may lag at 4x or below.
Why It Matters: Data is the backbone of modern healthcare, and tech enabling its flow or monetisation attracts premiums.
7. Aging Populations and Chronic Disease Focus
What’s Happening: Global demographics—aging populations and rising chronic conditions—drive demand for HealthTech like wearables, remote monitoring, and personalised medicine.
Impact on Multiples: Companies addressing these megatrends (e.g., diabetes management platforms) could see 6-7x multiples, outpacing the sector average. Less relevant players stay closer to 4-5x.
Why It Matters: Long-term market tailwinds justify higher valuations for firms tackling unavoidable healthcare challenges.
8. Cybersecurity and Privacy Emphasis
What’s Happening: High-profile healthcare data breaches and stricter privacy laws (e.g., GDPR, CCPA) are pushing HealthTech to prioritize security. Buyers scrutinise this closely.
Impact on Multiples: Firms with robust cybersecurity might gain a 0.5-1x boost (e.g., 5-6x vs. 4-5x), while vulnerabilities could slash valuations or kill deals.
Why It Matters: Trust and compliance are non-negotiable in healthcare, directly affecting buyer willingness to pay.
Nelson Advisors > Healthcare Technology M&A
.
Nelson Advisors specialise in mergers, acquisitions & partnerships for Digital Health, HealthTech, Health IT, Consumer HealthTech, Healthcare Cybersecurity, Healthcare AI companies based in the UK, Europe and North America. www.nelsonadvisors.co.uk
Nelson Advisors regularly publish Healthcare Technology thought leadership articles covering market insights, trends, analysis & predictions @ https://www.healthcare.digital
We share our views on the latest Healthcare Technology mergers, acquisitions & partnerships with insights, analysis and predictions in our LinkedIn Newsletter every week, subscribe today! https://lnkd.in/e5hTp_xb
Founders for Founders > We pride ourselves on our DNA as ‘HealthTech entrepreneurs advising HealthTech entrepreneurs.’ Nelson Advisors partner with entrepreneurs, boards and investors to maximise shareholder value and investment returns. www.nelsonadvisors.co.uk
#NelsonAdvisors #HealthTech #DigitalHealth #HealthIT #Cybersecurity #HealthcareAI #ConsumerHealthTech #Mergers #Acquisitions #Partnerships #Growth #Strategy #NHS #UK #Europe #USA #VentureCapital #PrivateEquity #Founders #BuySide #SellSide
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